In an attempt to get over a serious case of cold feet, Backpackers finds recently engaged Ryan (Noah Reid, Titanic) and Beth (Meghan Heffern, Almost Heroes) embarking on separate European adventures leading up to their wedding. While traveling they are free to act single, adopting the mantra "what happens in Europe, stays in Europe." But hours into Ryan's adventure with his party animal and womanizing best friend Brandon (Dillon Casey, Nikita), he realizes he's made a huge mistake and sets off in search of her. The only problem is he has no idea where she could be - they never exchanged itineraries. This marks the start of a wild adventure that takes the duo to the Amalfi coast, Rome, Berlin, Prague and Paris as they search for Beth, try to avoid an annoying Aussie, dodge a homicidal maniac and fit in a little action on the way.